Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

ADVANCED MEDICAL SOLUTIONS GROUP PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

 X

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to the notification obligation:

HARGREAVE HALE LIMITED

4. Full name of shareholder(s) (if different from 3.):

 DISCRETIONARY CLIENTS

5. Date of the transaction and date on which the threshold is crossed or reached:

 04 JANUARY 2010

6. Date on which issuer notified:

 05 JANUARY 2010

7. Threshold(s) that is/are crossed or reached:

 5%

8. Notified details:

A: Voting rights attached to shares

Class/type of

shares

if possible using

the ISIN CODE

Situation previous

to the triggering

transaction

Resulting situation after the triggering transaction

Number

of

Shares

Number

of

Voting

Rights

Number

of shares

Number of voting

rights

% of voting rights

Indirect

Direct

Indirect

Direct

Indirect

 GB0004536594

 7,037,750

 7,037,750

 7,737,750

 7,737,750

 5.3625%

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial

instrument

Expiration

date

Exercise/ 
Conversion 
Period

Number of voting

rights that may be

acquired if the

instrument is

exercised/ converted.

% of voting

rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial

instrument

Exercise 
price

Expiration 
date

Exercise/

Conversion 
period

Number of voting 
rights instrument 
refers to

% of voting rights

Nominal

Delta

Total (A+B+C)

Number of voting rights

Percentage of voting rights

 7,737,750

 5.3625%

9. Chain of controlled undertakings through which the voting rights and/or the

financial instruments are effectively held, if applicable:

5,300,000 of these shares are unit trusts operated by Marlborough Fund Managers Ltd for who Hargreave Hale Ltd manages the portfolio of investments on a discretionary basis.  The remaining balance is held on behalf of other discretionary clients.

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

 Holdings percentage based on TVR of 144,294,916

14. Contact name:

 David Clueit

15. Contact telephone number:

 01253 754739